At the end of 1992, she became more widely known while presenting both the talk show Mal ehrlich and the television sports magazine Sportpalast. At this time, she also worked for the Berlin TV station B1, while hosting the show Parlazzo at station WDR from 1996 to 1998.
Anne Will was the first woman to host the popular German sports show Sportschau since November 1999. During the 2000 Summer Olympics, she presented, on ARD, a variety of live sports shows from Sydney, Australia.
From 14 April 2001, to 24 June 2007, she presented the prime German broadcast late night news magazine Tagesthemen in alternation with Ulrich Wickert and, since September 2006, with his successor Tom Buhrow. Since 16 September 2007, she has been hosting her own political talkshow Anne Will in succession of the retired Sabine Christiansen. Her successor to Tagesthemen is Caren Miosga.
An active contributor to charities Kindernothilfe and UNICEF, she is also involved in projects aiming to eliminate landmines. She hosted the German stage event in front of the Siegessäule in Berlin of the Live8 on 2 July 2005.