Another common example is the reaction of a primary amine or secondary amine with a carboxylic acid or with a carboxylic acid derivative to form an amide. This reaction is widely used, especially in the synthesis of peptides. On the simple addition of an amine to a carboxylic acid, a salt of the organic acid and base is obtained. To overcome this, the carboxylic acid first needs to be "activated". This is usually done by converting the acid into a more reactive derivative (i.e. anhydride, acid halide) or by using a coupling agent. In some cases, high temperatures (>200 °C) can overcome salt formation by driving off water, without the need for "activation" of the carboxyl group. The downside to this simple reation is that the compounds may decompose at these elevated temperatures.
The carboxylic acid derivatives can be esters, anhydrides, acid halides or any other activated species.
The choice of activated carboxyl group or coupling agent can be very important in peptide synthesis, as using the wrong one can lead to racemization.
Enhancement of Hydrophilicity of PET Fabric by Sugar-Lactone, Part 2: Effects of Aminolysis on the Mechanical Strength and Hygroscopic Properties of PET Fabric
Jun 01, 2004; In an earlier paper, we found that a combination of aminolysis of PET fabric by ethylenediamine and a subsequent reaction...