4-Aminobenzoic acid (also known as para-aminobenzoic acid or PABA) is an organic compound with the molecular formula C₇H₇NO₂. PABA is a white crystalline substance that is only slightly soluble in water. It consists of a benzene ring substituted with an amino group and a carboxylic acid.

Functions

Organic

PABA is an essential nutrient for some bacteria and is sometimes called Vitamin B_x. However, PABA is not essential to human health, and is therefore not officially classified as a vitamin. Although humans lack the ability to synthesize folate from PABA, it is sometimes marketed as an essential nutrient under the promise that it can stimulate intestinal bacteria.

PABA is an intermediate in bacterial synthesis of folate. Sulfonamides are chemically similar to PABA, and their antibacterial activity is due to their ability to interfere with conversion of PABA to folate by dihydropteroate synthetase, and subsequent utilization, by bacteria.

Industrial

In the past, PABA has been widely used as a UV filter in sunscreen formulations. However, it has been determined that it increases the formation of a particular DNA defect in human cells, thus increasing the risk of skin cancer. Currently, safer and more effective derivatives of PABA, such as octyl dimethyl PABA, are more commonly used.

The potassium salt is used as a drug against fibrotic skin disorders under the trade name POTABA. PABA is also occasionally used in pill form by sufferers of Irritable bowel syndrome to treat its associated gastrointestinal symptoms, and in nutritional epidemiological studies to assess the completeness of 24-hour urine collection for the determination of urinary sodium, potassium, or nitrogen levels.

PABA also finds use in the manufacture of esters, folic acid, and azo dyes.

See also

• Aminomethylbenzoic acid
• 3-Aminobenzoic acid

References

External links

• PABA Cancer link