In enzymology, an alpha-L-fucosidase is an enzyme that catalyzes the chemical reaction

an alpha-L-fucoside + H2O rightleftharpoons L-fucose + an alcohol

Thus, the two substrates of this enzyme are alpha-L-fucoside and H2O, whereas its two products are L-fucose and alcohol.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is alpha-L-fucoside fucohydrolase. This enzyme is also called alpha-fucosidase. This enzyme participates in n-glycan degradation and glycan structures - degradation.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .


  • Levvy GA and McAllan A "Mammalian fucosidases. 2. alpha-L-Fucosidase". Biochem. J. 80 435–439.
  • Reglero A, Cabezas JA "Glycosidases of molluscs. Purification and properties of alpha-L-fucosidase from Chamelea gallina L". Eur. J. Biochem. 66 379–87.
  • Tanaka K, Nakano T, Noguchi S, Pigman W "Purification of alpha-L-fucosidase of abalone livers". Arch. Biochem. Biophys. 126 624–33.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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