Non-selective Adrenergic blockers:
Tamsulosin is relatively selective for α1a-adrenergic receptors, which are mainly present in the prostate. Hence, it may have a more selective action in BPH with minimal effects on blood pressure.
Because these medications may cause orthostatic hypotension, as well as hypotension in general, these agents may interact with other medications that increase risk for hypotension, such as other antihypertensives and vasodilators.
As discussed above, tamsulosin may have less risk for hypotension and orthostatic hypotension due to its selectivity for α1a-adrenergic receptors. On the other hand, the drug (a) elevates risk for floppy iris syndrome, and (b) might show ADRs characteristic of the sulfa related drugs.
Diuretic suggested as initial hypertension treatment: increased use of diuretics could save billions.(thiazides recommended as initial therapy)
Mar 01, 2003; The largest hypertension trial ever conducted is recommending thiazide diuretics as initial therapy over newer, more costly...