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PYODERMA - 2 reference results
Pyoderma gangrenosum
Pyoderma gangrenosum is a disease that causes tissue to become necrotic, causing deep ulcers that usually occur on the legs. When they occur, they can lead to chronic wounds. Ulcers usually initially look like small bug bites or papules, and they progress to larger ulcers. Though the wounds rarely lead to death, they can cause pain and scarring.

The disease was identified in 1930. It affects approximately 1 person in 100,000 in the population. Though it can affect people of any age, it mostly affects people in their 40s and 50s.

Types

There are two main types of pyoderma gangrenosum:

  • the normal ulcerative form, which occurs in the legs
  • an 'atypical' form that is more superficial and occurs in the hands and other parts of the body

Other variations are:

  • Peristomal pyoderma gangrenosum is 15% of all cases of pyoderma
  • Bullous pyoderma gangrenosum
  • Pustular pyoderma gangrenosum
  • Vegetative pyoderma gangrenosum

Causes

Though the etiology is not well understood, the disease is thought to be due to immune system dysfunction, and particularly improper functioning of neutrophils. At least half of all pyoderma gangrenosum patients also suffer from illnesses that affect their systemic function. For instance, ulcerative colitis, Crohn's disease, rheumatoid arthritis, myeloma sufferers have the condition.

Associations

The common conditions associated with pyoderma gangrenosum are:

  • Inflammatory bowel disease:

    • Chronic ulcerative colitis
    • Crohn's disease
  • Arthritides:

    • Rheumatoid arthritis
    • Seronegative symmetrical polyarthritis
  • Haematological disease:

    • Myelocytic leukaemia
    • Hairy cell leukaemia
    • Myelofibrosis
    • Myeloid metaplasia
    • Monoclonal gammopathy (IgA)

Treatment

A number of treatment options exist.

References

External links

Wikipedia, the free encyclopedia © 2001-2006 Wikipedia contributors (Disclaimer)
This article is licensed under the GNU Free Documentation License.
Last updated on Saturday October 04, 2008 at 09:01:18 PDT (GMT -0700)
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Managing difficult cases of canine pyoderma
Jan 01, 2002; PEER-REVIEWED The term pyoderma refers to a pus-producing, or pyogenic, bacterial infection of the skin. In the dog, pyoderma is...
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Pyoderma gangrenosum and anticardiolipin antibody.
Apr 01, 2006; Byline: Jose Maria. de Godoy, Fernando. Batigalia, Domingo. Braile Pyoderma gangrenosum (PG) is a rare ulceronecrotic...
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Clinical appearance of recurrent bacterial pyoderma can vary by patient
Mar 01, 2001; DERMATOLOGY Although recognizing a bacterial pyoderma in a canine patient is relatively easy, eradicating the pyoderma can be...
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In-vitro activities of current antimicrobial agents against isolates of pyoderma
Jul 01, 2008; Sir, Pyoderma is a common health problem characterized by pyogenic infection of the skin and its appendages. Though easily...
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Research from Z.H. Liu and co-researchers yields new findings on pyoderma gangrenosum.
Nov 05, 2008; Pyoderma gangrenosum is a rare, painful, noninfectious, ulcerative, reactive neutrophilic skin condition. It is characterized by...
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