The United States Secretary of Health, Education, and Welfare was the head of the United States Department of Health, Education, and Welfare. The Secretary was a member of the President's Cabinet. In 1979, there was a division of the Secretary of Health, Education, and Welfare's position into separate secretaries of Health and Human Services and Education.
| No. | Name | Year appointed | President(s) served under |
|---|---|---|---|
| 1 | Oveta Culp Hobby | Dwight D. Eisenhower | |
| 2 | Marion Bayard Folsom | Dwight D. Eisenhower | |
| 3 | Arthur Sherwood Flemming | Dwight D. Eisenhower | |
| 4 | Abraham A. Ribicoff | John F. Kennedy | |
| 5 | Anthony J. Celebrezze | John F. Kennedy, Lyndon Johnson | |
| 6 | John William Gardner | Lyndon Johnson | |
| 7 | Wilbur J. Cohen | Lyndon Johnson | |
| 8 | Robert H. Finch | Richard Nixon | |
| 9 | Elliot Lee Richardson | Richard Nixon | |
| 10 | Caspar Weinberger | Richard Nixon, Gerald Ford | |
| 11 | Forrest David Mathews | Gerald Ford | |
| 12 | Joseph A. Califano, Jr. | Jimmy Carter | |
| 13 | Patricia Roberts Harris | Jimmy Carter |