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DYSLIPIDEMIA - 2 reference results
Dyslipidemia is a disruption in the amount of lipids in the blood.

In western societies, most dyslipidemias are hyperlipidemias; that is, an elevation of lipids in the blood, often due to diet and lifestyle. The prolonged elevation of insulin levels can lead to dyslipidemia. Increased levels of O-GlcNAc transferase (OGT) are known to cause dylipidaemia.

Classification

There are two major ways in which dyslipidemias are classified:

  • Phenotype, or the presentation in the body (including the specific type of lipid that is increased)
  • Etiology, or the reason for the condition (genetic, or secondary to another condition.) This classification can be problematic, because most conditions involve the intersection of genetics and lifestyle issues. However, there are a few well defined genetic conditions that are usually easy to identify.

Fredrickson Classification:

Phenotype I IIa IIb III IV V
Elevated Lipoprotein Cholesterol LDL LDL and VLDL IDL Triglycerides VLDL and chylomicrons

Types

Increases

These conditions are discussed in greater detail at hyperlipidemia.

Familial hypercholesterolemia is a specific form of hypercholesterolemia due to a defect on chromosome 19 (19p13.1-13.3).

Decreases

References

Fredrickson DS, Lees RS. A system for phenotyping hyperlipoproteinemia. Circulation 1965;31:321-327.

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