DYSLIPIDEMIA - 2 reference results
Dyslipidemia is a disruption in the amount of lipids in the blood.
In western societies, most dyslipidemias are hyperlipidemias; that is, an elevation of lipids in the blood, often due to diet and lifestyle. The prolonged elevation of insulin levels can lead to dyslipidemia. Increased levels of O-GlcNAc transferase (OGT) are known to cause dylipidaemia.
Classification
There are two major ways in which dyslipidemias are classified:
- Phenotype, or the presentation in the body (including the specific type of lipid that is increased)
- Etiology, or the reason for the condition (genetic, or secondary to another condition.) This classification can be problematic, because most conditions involve the intersection of genetics and lifestyle issues. However, there are a few well defined genetic conditions that are usually easy to identify.
Fredrickson Classification:
| Phenotype | I | IIa | IIb | III | IV | V |
|---|---|---|---|---|---|---|
| Elevated Lipoprotein | Cholesterol | LDL | LDL and VLDL | IDL | Triglycerides | VLDL and chylomicrons |
Types
Increases
- These conditions are discussed in greater detail at hyperlipidemia.
- Hyperlipidemia: lipids
- Hypercholesterolemia: cholesterol
- Hyperglyceridemia: glycerides
- Hypertriglyceridemia: triglycerides
- Hyperlipoproteinemia: lipoproteins (usually LDL unless otherwise specified)
- Hyperchylomicronemia: chylomicrons
- Combined hyperlipidemia: both LDL and triglycerides
Familial hypercholesterolemia is a specific form of hypercholesterolemia due to a defect on chromosome 19 (19p13.1-13.3).
Decreases
- Hypolipoproteinemia: lipoproteins
- Hypocholesterolemia: cholesterol
- Abetalipoproteinemia: beta lipoproteins
- Tangier disease: high density lipoprotein
References
Fredrickson DS, Lees RS. A system for phenotyping hyperlipoproteinemia. Circulation 1965;31:321-327.
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Last updated on Saturday September 20, 2008 at 14:45:50 PDT (GMT -0700)
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