Dictionary
Thesaurus
Reference
Translate
Web
Related Searches
on Ask.com
AMILORIDE - 2 reference results
Amiloride

Amiloride is a potassium-sparing diuretic, first approved for use in 1967 (then known as MK 870), used in the management of hypertension and congestive heart failure.

Structure

Amiloride is a guanidinium group containing pyrazine derivative.

Mode of action

Amiloride works by directly blocking the epithelial sodium channel (ENaC) thereby inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys (this mechanism is the same for triamterene). This promotes the loss of sodium and water from the body, but without depleting potassium. The drug is often used in conjunction with thiazide (e.g. co-amilozide) or loop diuretics (e.g. co-amilofruse). Due to its potassium-sparing capacities, hyperkalemia (high blood potassium levels) are occasionally observed in patients taking amiloride. The risk is high in concurrent use of ACE inhibitors or spironolactone. Patients are also advised not to use potassium-containing salt replacements. Amiloride also carries the risk of developing an acidosis.

A fraction of the effects of amiloride is inhibition of cyclic GMP-gated cation channels in the inner medullary collecting duct.

See also

References

Wikipedia, the free encyclopedia © 2001-2006 Wikipedia contributors (Disclaimer)
This article is licensed under the GNU Free Documentation License.
Last updated on Tuesday September 30, 2008 at 06:41:46 PDT (GMT -0700)
View this article at Wikipedia.org - Edit this article at Wikipedia.org - Donate to the Wikimedia Foundation

Ionic interaction of amiloride and UTP in nebulizer solution characterized.
Nov 03, 2004; 2004 NOV 3 - (NewsRx.com & NewsRx.net) -- The ionic interaction of amiloride and UTP in nebulizer solution has been...
Read more with a free trial on HighBeam.com »
Blood pressure drug Amiloride could treat MS: research
Nov 12, 2007; Blood pressure drug Amiloride could treat MS: research LONDON, Nov. 12 (Xinhua) -- Amiloride, a drug used for decades to treat...
Read more with a free trial on HighBeam.com »
Mechanisms of cardiodepression by an [Na.sup.+]-[H.sup.+] exchange inhibitor methyl-N-isobutyl amiloride (MIA) on the heart: lack of beneficial effects in ischemia-reperfusion injury (1).
Jan 01, 2007; Abstract: Although [Na.supH.sup exchange (NHE) inhibitors such as methyl-N-isobutyl amiloride (MIA) are known to depress the...
Read more with a free trial on HighBeam.com »
PHARMACEUTICAL RESOURCES, INC. LAUNCHES THREE PRODUCTS (AMILORIDE HCI, GLIPIZIDE, AND CIMETIDINE)
Oct 16, 1995; Through its Agreement with Mova Pharmaceutical Corp. SPRING VALLEY, N.Y., Oct. 16 /PRNewswire/ -- Pharmaceutical Resources, Inc....
Read more with a free trial on HighBeam.com »
amiloride
Jan 01, 2008; amiloride x103;- mil x14F;-ryd) n. a potassium-sparing diuretic that causes the increased excretion of sodium and chloride; it is...
Read more with a free trial on HighBeam.com »
HighBeam Research, Inc. © Copyright 2009.

Search another word or see AMILORIDE on Dictionary | Thesaurus