Spine or Spinal may refer to:
- Vertebral column, commonly known as the backbone
- The Spine, a set of national services used by the NHS Care Record Service (an electronic patient record system)
- The Spine, a 2004 They Might Be Giants album, including the songs "Spine" and "Spines"
- Spinal Tap (band), a semi-fictional heavy metal band
- Spinal (Killer Instinct), a fictional character from the video game Killer Instinct
- Spine, a demon in Blood Beast, 2007 book of the Demonata saga
- There are 5 sections in the spine