D-alanine-poly(phosphoribitol) ligase

ATP + D-alanine + poly(ribitol phosphate) $rightleftharpoons$ AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate)

The 3 substrates of this enzyme are ATP, D-alanine, and poly(ribitol phosphate), whereas its 3 products are AMP, diphosphate, and O-D-alanyl-poly(ribitol phosphate).

This enzyme belongs to the family of ligases, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is D-alanine:poly(phosphoribitol) ligase (AMP-forming). Other names in common use include D-alanyl-poly(phosphoribitol) synthetase, D-alanine: membrane acceptor ligase, D-alanine-D-alanyl carrier protein ligase, D-alanine-membrane acceptor ligase, and D-alanine-activating enzyme. This enzyme participates in d-alanine metabolism.

References

• BADDILEY J, NEUHAUS FC "The enzymic activation of D-alanine". Biochem. J. 75 579–87.
• Reusch VM Jr, Neuhaus FC "D-Alanine: membrane acceptor ligase from Lactobacillus casei". J. Biol. Chem. 246 6136–43.
• Perego M, Glaser P, Minutello A, Strauch MA, Leopold K, Fischer W "Incorporation of D-alanine into lipoteichoic acid and wall teichoic acid in Bacillus subtilis. Identification of genes and regulation". J. Biol. Chem. 270 15598–606.
• Heaton MP, Neuhaus FC "Role of the D-alanyl carrier protein in the biosynthesis of D-alanyl-lipoteichoic acid". J. Bacteriol. 176 681–90.
• Debabov DV, Heaton MP, Zhang Q, Stewart KD, Lambalot RH, Neuhaus FC "The D-Alanyl carrier protein in Lactobacillus casei: cloning, sequencing, and expression of dltC". J. Bacteriol. 178 3869–76.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes