An example of a cause of this disorder would be an olfactory groove meningioma. It is also seen in the final stages of Creutzfeldt-Jakob Disease (a rare degenerative brain disease), and in acute cases of encephalitis lethargica. It can also occur in a stroke that affects both anterior cerebral territories.
Another cause of both akinesia and mutism is ablation of the cingulate gyrus. Destruction of the cingulate gyrus has been used in the treatment of psychosis. Such lesions result in akinesia, mutism, apathy, and indifference to painful stimuli.