• Aggravation, a board game played with marbles
• Aggravation, a Game Boy Advance game based on the board game
• Aggravation, a Nintendo DS game based on the board game
• Aggravation, a cocktail made from whiskey, coffee liqueur and cream
• Aggravation, an 1896 painting by British artist Briton Rivière
• Aggravation (legal concept), a concept in criminal law

In medicine:

• Aggravation, worsening of a symptom
• Aggravation, also known as a 'healing crisis', a doctrine in classical homeopathy

In music:

• Aggravation, a 1966 single by English musician Chris Curtis
• Aggravation, a 1973 song by American singer Martha Veléz
• Aggravation, a 1989 song by The Kinks from their album UK Jive
• Aggravation, a 1991 album by French band Treponem Pal

Aggravation may also refer to:

• Aggravation Boulevard, a notable sketch from 1950s American comedy show Caesar's Hour
• Aggravation of class struggle under socialism
• Aggravation Plantation, a 2007 single by Canadian reggae/heavy metal band Brown Brigade
• Mutual Aggravation Society, a 1984 spoof song from album Forbidden Broadway, Vol. 1
• The Aggravation Song, a 2005 song by Fran Smith Jr.

See also:

• Aggro
• Aggrovation, also known as Aggi Dukes, British rap artist