Camphoric acid, C10H16O4 or in Latin form Acidum camphoricum, is a white crystallisable substance obtained from the oxidation of camphor, it exists in three optically different forms; dextrorotatory one is obtained by the oxidation of dextrorotatory camphor and used in pharmaceuticals.
Acidum camphoricum was studied and isolated for the first time by French pharmacist Nicolas Vauquelin
in the early 1800s but it wasn't until September of 1874 that Dutch chemist Jacobus H. van 't Hoff
proposed the first suggestion for its molecular structure and optical properties. In 1904 Finnish
chemist Gustav Komppa
became the first to succeed in manufacturing camphor
from this acid.
Chemical properties and isolation
Camphoric acid may be prepared by oxidising camphor with nitric acid
This acid has a mild camphor action; it is not very toxic and can be used in very large doses, up to 4 grammes
), without serious effects; it is supposed to paralyse the nerve-endings in the sweat glands
, and is used in the night-sweats of phthisis
It does not affect other secretions
as does atropine
, nor irritate the stomach
like agaric acid
. Camphoric acid is also employed in solution
, 0.2 to 5.0 percent by weight or volume, with sufficient alcohol
, as a local antiseptic
to the nose
, and bladder
, among other uses, is usually administered as a powder, or in cachets
, but may also be given in mixtures suspended with compound powder of tragacanth
, or dissolved by the addition of diluted alcohol or a flavouring tincture
. When used as an antihydrotic
the dose should be given two or three hours before bedtime.
- Acidum camphoricum. The British Pharmaceutical Codex. .
- Camphoric acid. Science and Technology. .
- Camphoric acid. Taiwan Tekho Camphor Co. .
- Jacobus Henricus van 't Hoff (1874). "A suggestion looking to the extension into space of the structural formulas at present used in chemistry. And a note upon the relation between the optical activity and the chemical constitution of organic compounds". Archives neerlandaises des sciences exactes et naturelles 9 445–454.