In broadcast media:

• Against the Grain (TV series), 1993 NBC drama series with Ben Affleck
• Against the Grain (radio program), an interview program on Pacifica Radio station KPFA, Berkeley, hosted by C.S. Soong

In music:

• Against the Grain (Snakefinger album), 1983 album by the musician Snakefinger
• Against the Grain (Bad Religion album), 1990 album by the band Bad Religion
• Against The Grain (Acoustic Alchemy album), 1994 album by the band Acoustic Alchemy
• Against The Grain (Rory Gallagher album), album by Rory Gallagher
• Against the Grain (record label), British breakbeat record label
• "Against the Grain", song by country-western singer Garth Brooks on his 1991 album Ropin' the Wind

Books:

• Against the Grain: Mad Artist Wallace Wood, edited by Bhob Stewart
• Against the Grain, one English title of À rebours, Symbolist novel by Joris-Karl Huysmans, also known as Against Nature, the second English title
• Against the Grain: An Autobiography, by Boris Yeltsin
• Against the Grain: How Agriculture Has Hijacked Civilization, by Richard Manning