Affliction is a title of several works of fiction:

Films

• Affliction (1997 film), a 1997 film based on the 1989 novel by Russell Banks.

Television

• "Affliction (Enterprise episode)", a fourth season episode of Star Trek: Enterprise.

Music

• Afflicted, a Swedish death metal band.
• Affliction (band), a British alternative rock band.
• Affliction EP - The second EP from UK metal band Carcer City.

MMORPG World Of Warcraft

• Affliction being a talent tree of the Warlock class of character in the widely popular MMORPG (massive multiplayer online role playing game) World Of Warcraft. Affliction warlocks rely heavily on spells known as DoT's (Damage over Time) spells.

MMORPG Guild Wars

• Commonly referred to as "The Plague" as it sweeps across the continent of Cantha in the Factions campaign. It is used by the main antagonist, Shiro, as a tool to build an afflicted army.

Clothing

• Affliction Clothing, a brand of clothing.

Magazine

• Affliction Magazine, a publication dedicated to Mixed Martial Arts.

Athletics

• Affliction: Banned, a mixed martial arts event co-promoted by Affliction Clothing and Adrenaline MMA.