RRNA (adenosine-2'-O-)-methyltransferase

S-adenosyl-L-methionine + rRNA $rightleftharpoons$ S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine

Thus, the two substrates of this enzyme are S-adenosyl methionine and rRNA, whereas its two products are S-adenosylhomocysteine and rRNA containing a single residue of 2'-O-methyladenosine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase. Other names in common use include ribosomal ribonucleate adenosine 2'-methyltransferase, rRNA adenosine 2'-methylase, RNA-pentose methylase, and thiostrepton-resistance methylase.

References

• Thompson J and Cundliffe E "Purification and properties of an RNA methylase produced by Streptomyces azureus and involved in resistance to thiostrepton". J. Gen. Microbiol. 124 291–297.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes