Fatty acid + CoA + ATP <=> Acyl-CoA + AMP + PPi
has a free energy change near zero. Subsequent hydrolysis of the product PPi (by the enzyme inorganic pyrophosphatase) is highly exergonic, and this reaction makes the formation of acyl-CoA spontaneous and irreversible.
Fatty acids are activated in the cytosol, but oxidation occurs in the mitochondria. Because there is no transport protein for CoA adducts, acyl groups must enter the mitochondria via a shuttle system involving the small molecule carnitine.
WIPO ASSIGNS PATENT TO SUNTORY HOLDINGS FOR "POLYNUCLEOTIDE ENCODING ACYL-COA SYNTHETASE HOMOLOG AND METHOD FOR USING THE SAME" (JAPANESE INVENTOR)
Aug 06, 2011; GENEVA, Aug. 6 -- Publication No. WO/2011/093509 was published on Aug. 04. Title of the invention: "POLYNUCLEOTIDE ENCODING...
US Patent Issued to Metabolix on Aug. 31 for "Production of Medium Chain Length Polyhydroxyalkanoates from Fatty Acid Biosynthetic Pathways" (American, Canadian Inventors)
Sep 01, 2010; ALEXANDRIA, Va., Sept. 2 -- United States Patent no. 7,786,355, issued on Aug. 31, was assigned to Metabolix Inc. (Cambridge,...