The non-sarcomeric α-actinins (ACTN1 and ACTN4) are widely expressed. Both ends of the rod-shaped α-actinin dimer contain actin-binding domains.
Mutations in ACTN4 can cause the kidney disease focal segmental glomerulosclerosis.
The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3.(Research)
Aug 07, 2008; Authors: Sunita K Agarwal (corresponding author) ; William F Simonds ; Stephen J Marx BackgroundParafibromin is encoded...
Mechanics and multiple-particle tracking microheterogeneity of (alpha)-actinin-cross-linked actin filament networks
Sep 01, 2001; ABSTRACT Cell morphology is controlled by the actin cytoskeleton organization and mechanical properties, which are regulated by...