Abomination may refer to:

• Abomination (Bible), covering Biblical references
• Abomination, a Vampire/Werewolf hybrid from the game Werewolf: The Apocalypse
• Abomination (Dune), from Frank Herbert's Dune series, a fetus who has become conscious before birth
• Abomination (Dungeons & Dragons), the offspring of deities and some other being in the Dungeons & Dragons role-playing game
• Abomination (comics), a Marvel Comics supervillain
• Abomination: The Nemesis Project, a real time strategy computer game
• The Abomination, a novel by Paul Golding
• Abomination (Novel)-A novel by Robert Swindells
• Abomination (Warcraft 3), The twisted, mutilated bodies of the Abominations are comprised of multiple dead limbs and body parts from various corpses. A playable unit in W3
• An epithet for the Animorphs character Visser Three, primarily used by Aximili-Esgarrouth-Isthill, referring to his status as an Andalite-Controller