Regarded as one of the creators of the most influential cult noirè, exeprimental, intelligent style literature in Latin America, he wrote as a novelist, poet, critic, playwright, and journalist. His most famous novels are Farabeuf (1965) and El hipogeo Secreto (1968). He is also known for El grafógrafo (1972) which is a series of short texts based on linguistic abbreviatory experimentation.
His style is considered innovative among Mexican contemporary literature for introducing a cosmopolitan view of language and narrative, bringing elements from external literary currents and languages to a refined dialogue of thought and communication. His technique is considered rather unrealistic and proto-fictional, as opposed to magical realism. His works are associated with writers such as Ezra Pound, James Joyce, Julio Cortazar, Juan Rulfo and Georges Bataille. He was also a Professor at UNAM for 25 years and received many international grants, such as the Guggenheim and Rockefeller, and was the recipient of the 1990 national prize of literature. Elizondo died in Mexico City on March 29, 2006, of cancer. His funeral was held at the palacio de Bellas Artes.