Zoë predominantly distributes albums by folk rock and alternative pop artists. Artists who have released albums on the label include Lisa Loeb, Grant Lee Phillips, Juliana Hatfield, Jules Shear and The Nields.
Pre-teen pop girl group, Girl Authority were also released on the label.
Zoë is also the American distributor for releases by a number of Canadian artists who have separate deals with major or independent labels in Canada, such as Jann Arden, Cowboy Junkies, Sarah Harmer, Kathleen Edwards, Great Big Sea, The Cash Brothers and The Tragically Hip. The record label is named after Zoë Virant, the daughter of CEO John Virant and member of pop group Girl Authority.