Yaneura no nishojo (屋根裏の二處女 "Two Virgins in the Attic", 1919) is semi-autobiographical, and describes a female-female love experience with her dormmate. In the last scene, the two girls decide to live together as a couple. This work, in attacking male-oriented society, and showing two women as a couple after they have finished secondary education presents a strong feminist attitude, and also reveals Yoshiya's own lesbian sexual orientation.
Her Chi no hate made ("To the Ends of the Earth", 1920), won a literary prize by the Osaka Asahi Shimbun, and reflects some Christian influence.
In 1925, Yoshiya began her own magazine, Kuroshoubi (Black Rose), which she discontinued after eight months.
Yoshiya's other major works include Onna no yujo ("Women's Friendship", 1933-1934), Otto no Teiso (良人の貞操 "A Husband's Chastity", 1936-1937), Onibi (鬼火 "Demon Fire", 1951), Atakake no hitobito (安宅家の人々 "The Ataka Family", 1964-1965), Tokugawa no fujintachi (徳川の夫人たち "Tokugawa Women", 1966) and Nyonin Heike (女人平家 "Ladies of the Heike", 1971)
Although not all of Yoshiya's works depict same-sex romance between girls, even in plots with heterosexual domestic melodrama, her novels tended to avoid depictions of marriage. Her writing style was marked by onomatopoeia, exclamation points and other unusual diacritical marks, which were considered aesthetically appealing by her female readers, and were part of a movement to introduce realistic dialogue into stories. Her use of imagery, especially in setting scenes in unexpected locations, such as an attic or veranda, aided in creating a melodramatic atmosphere.
Yoshiya's stories were considered "respectable" texts, suitable for consumption by girls and women of all ages, as the lesbian attachments are depicted as emotionally intense yet platonic relationships, destined to be curtailed by graduation from school, marriage, and/or death. This can be explained in part by the contemporary understanding that same-sex love was a transitory and "normal" part of female development leading into heterosexuality and motherhood.
Yoshiya made no secret of her own lifelong relationship with a same-sex partner, Kadoma Chiyo, and unlike many Japanese public persona, was not reticent about revealing details of her personal life through photographs, personal essays and magazine interviews.
Yoshiya lived in Kamakura, Kanagawa prefecture during World War II. In 1962 she built a traditional wooden house with Japanese-style garden in a quiet setting, which she willed to the City of Kamakura on her death, to be used to promote women's cultural and educational activities. The house is now the Yoshiya Nobuko Memorial Museum, and preserves the study as she left it, with items such as handwritten manuscripts and favorite objects are on display. However, the museum is open only twice a year, in early May and November, for three days each time.