Studying the lyrics of the title track, "S-E-X-X-Y" appears to revolve around an attractive woman, however one popular interpretation of the track is it is in fact about someone who has Klinefelter's syndrome - a person with two X chromosomes and a Y chromosome, or possibly about a transvestite, as evidenced by the final lyrics of the song: "You gotta understand/She wants to be your man/She's got another plan." However, They Might Be Giants have claimed that this song is simply an "ode to getting it on." The song states that "X, because it's extra, baby. Y, because it's extra, baby.", implying S-E-X.