Bryant-Woolridge made her debut as a novelist in 1999 when she published the novel Read Between the Lies. The book went on to become a best-seller, and in 2000 was nominated for a Golden Pen Award for Best Contemporary Fiction. Her second novel, Hitts & Mrs., was published in 2004, and made the Essence Magazine bestseller list. Bryant-Woolridge's latest work, the novel Weapons of Mass Seduction was published in April 2007.
Bryant-Woolridge has also contributed to several anthologies, such as Gumbo: A Celebration of African-American Writing (Harlem Moon, 2002), and Brown Sugar 3: Opposites Attract (Washington Square, 2004).
In the Spring of 2005, Bryant-Woolridge co-founded the Femme Fantastik Literary Tour, a book tour dedicated to showcasing the work of female authors of color.
Bryant-Woolridge spent her early career in various television production and management roles at the ABC Television Network, Public Broadcasting System (PBS), and Black Entertainment Television (BET). In 1983, Bryant-Woolridge was honored with the Emmy Award for Individual Achievement in Writing.
She is the co-founder of Mothers Off Duty, a non-profit women's organization committed to aiding in the prevention of teen pregnancy and the promotion of continued education and parental responsibility.