Whey Acidic Protein contains two to three four-disulfide core domain, also termed WAP domain or WAP motif. Each disulfide bond of the WAP motif is made up of two cysteine molecule. This motif is also found in other proteins of different functions, which led to the suggestion that WAP is associated with antiprotease or antibacterial properties.
It has been found that humans and ruminants has the WAP gene in their genome as pseudogene. Although humans and ruminants do not seem to encode the gene, there is no detrimental effect. However, mouse pups feeding on maternal milk lacking Whey Acidic Protein has been associated with poor growth rate and lethality.
Perlwapin, an Abalone Nacre Protein with Three Four-Disulfide Core (Whey Acidic Protein) Domains, Inhibits the Growth of Calcium Carbonate Crystals
Oct 01, 2006; ABSTRACT We have isolated a new protein from the nacreous layer of the shell of the sea snail Haliotis laevigata (abalone). Amino...
5'-flanking regions of camel milk genes are highly similar to homologue regions of other species and can be divided into two distinct groups
Feb 01, 2003; ABSTRACT The concentrations of individual casein and whey proteins in camel milk differ markedly to respective protein...