Passenger services are provided by Northern Rail.
Access to the station is by a dead-end road from Wetheral village green, or by a footpath from the B6263 opposite Plains Road. A footbridge links the two platforms. Corby Bridge (popularly known as 'Wetheral Viaduct'), over which trains pass when leaving the station towards Newcastle, has a footpath that links the station with the nearby village of Great Corby.
The station has approximately seven trains every day stopping in each direction. Other faster passenger trains and goods trains pass through without stopping. Trains that stop at Wetheral also stop at all other stations west of Hexham on the Tyne Valley line. Passengers for stations between Hexham and Newcastle usually have to change at Hexham.
The station was originally staffed, and the old stationmaster's house still stands, as a private residence. The boarded up ticket windows are still visible. The station was closed during the Beeching Axe (in 1967) but reopened in 1981 on an unstaffed basis.