The Weerman degradation
is an organic reaction
in carbohydrate chemistry
in which an aldonamide (derived from an aldonic acid
) is degraded by sodium hypochlorite
forming a new sugar with one less carbon. The reaction is named after R.A. Weerman
The reaction mechanism is that of the related Hofmann degradation. One study demonstrated the direct oxidation of glucose to arabinose by the same sodium hypochlorite skipping the aldonic acid and aldoamide steps.