Weerman degradation

Weerman degradation

The Weerman degradation is an organic reaction in carbohydrate chemistry in which an aldonamide (derived from an aldonic acid) is degraded by sodium hypochlorite forming a new sugar with one less carbon. The reaction is named after R.A. Weerman

The reaction mechanism is that of the related Hofmann degradation. One study demonstrated the direct oxidation of glucose to arabinose by the same sodium hypochlorite skipping the aldonic acid and aldoamide steps.


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