The first chairman of the Board was Donald M. Nelson from 1942 to 1944 followed by Julius A. Krug from 1944 until the Board was dissolved.
In 1943, the WPB hired Harvard Business School Professor Thomas North Whitehead to tour the nation and find out how Americans were reacting to rationing and controls. Whitehead reported that "the good temper and common sense of most people under restrictions and vexations was really impressive... My own observation is that most people are behaving like patriotic, loyal citizens."
Soviet intelligence penetrated the War Production Board, including several members of the Perlo group and its head Victor Perlo. The Moynihan Commission on Government Secrecy in 1995 referred to this as a serious attack on American security by the Soviet Union, with considerable assistance from an enemy within. The head of the Silvermaster group, Nathan Gregory Silvermaster also penetrated the agency. The following list are American citizens who were engaged in espionage activities on behalf of the Soviet Union while working for the War Production Board. Its code name as deciphered in the Venona project is the "Depot".