Since then, his illustrative talents in comics have included The Sandman, American Freak, Batman, Witchcraft: Le Terreur, The Spectre, and A History of Violence, which was later made into a movie directed by David Cronenberg and starring Viggo Mortensen. Recently he has done work for 2000 AD, including one Judge Dredd story.
Locke has also gained notoriety by creating ultra-violent watercolor paintings to be used as album covers for the death metal band Cannibal Corpse. Also, he has provided illustrations for the "weird erotica" of dark-fantasy author Caitlín R. Kiernan, providing black and white artwork strongly reminiscent of Aubrey Beardsley's style for her collections Frog Toes and Tentacles and Tales from the Woeful Platypus, as well as for Kiernan's monthly Sirenia Digest. Recent projects have included illustrating the first issue of Polluto: The Anti-Pop Culture Journal. He is also known for providing art work for RPGs by White Wolf and Wizards of the Coast.
He lives with his wife and son in Michigan, where he continues to draw and paint.
Comics work includes: