In these years he participated in social gatherings directed by Marcelo Macías, with other intellectuals, such as Xulio Alonso Cuevillas or Arturo Vázquez Núñez, who would significantly influence Vicente Risco's literary career. He read decadent English and French authors, who exposed him to occultism and orientalism. He also studied Buddhism and became a Theosophist author.
In 1910 he began work for a local newspaper, El Miño, where he wrote philosophical articles under the pseudonyms Rujú Sahib and Polichinela. He became a follower of Rabindranath Tagore, announcing the fact in the intellectual social gatherings of Ourense.
In 1916 he finished his studies and he returned to Ourense as a professor of history. In 1917 he founded, along with Arturo Noguerol Román, the literary magazine La Centuria, an antecedent of the future nationalist magazine Nós.
In 1920 he published the book Theory of Galician Nationalism, considered the foundational text of Galician nationalism. Risco took ideas from Murguía and combined them with philosophical irrationalism, geographic determinism, neotraditionalism and ethnography; he defined the nation as a natural entity based on land, race, language, social organization, and national sentiment. He valued Galicia's geographical and cultural connection to Celtic history and the Atlantic region, as opposed to Spain's Mediterranean heritage.
In 1920 he started the magazine Nós, where he wrote over 100 articles until its cancellation in July 1936. He also directed the ethnographic section of the Seminario de Estudos Galegos. In 1922 he married María Carme Fernández Gómez. In 1923 his first son, Antón Risco, was born.
Risco initially supported the dictatorship of Miguel Primo de Rivera, because he saw in it the opportunity to destroy the caciquist system and accept the role of provincial deputy in Ourense thinking of the possibility of the establishment of a Commonwealth of Galicia, similar to the Commonwealth of Catalonia.After his rupture with the Irmandade da Fala da Coruña and A Nosa Terra he wrote for Rexurdimento, the newspaper of the Irmandade Nazonalista Galega (Galician Nationalist Brotherhood), although he returned to A Nosa Terra after a short time.
In April 1930 he travelled to Berlin, living there for four months and delivering a course in ethnography at the University of Berlin. After that he became more conservative and Catholic. He wrote a book, Mitteleuropa, in which he described his European trip.
In 1933 he published Nós, os inadaptados, in which he expounded his spiritual and cyclical conception of history.
In the Third Assembly of the PG (October 1935), he accepted temporary collaboration with the left-wing parties to avoid the dissolution of the PG. In January 1935 he published an article in the Heraldo de Galicia, where he called for the reconquest of Galicia by God. In confrontation with the leaders of his party he didn't attend the IV Assembly of the PG in Monforte de Lemos. It was during that assembly the accords with left-wing parties were ratified. In the extraordinary Assembly of Santiago in February 1936 the PG formed a coalition with the Popular Front. Risco united with the group of right-wing Galicianists, and he left the PG to direct Dereita Galeguista.
On June 13, 1936, when the campaign began to establish the Statute of Autonomy of Galicia, he supported the affirmative vote. When the Civil War began, he did nothing to help his Galicianist friends that were murdered or imprisoned. From 1937 he directed Misión, founded with Otero Pedraio. After 1938 he started to write articles for La Región where he supported Franco's band. As a result, old Galicianist friends regarded him as a traitor. This is symbolized in the phrase of Castelao in his book Sempre en Galiza: "...said Risco, when Risco was somebody".
With the help of Galicianist friends Otero Pedrayo and Francisco Fernández del Riego, he again started writing in Galician: in his ethnographic studio he wrote History of Galiza directed by Otero Pedrayo, and translated Camilo José Cela's book The family of Pascual Duarte, completed in 1951.
Nevertheless, Castilian would be the language employed in the rest of his literary production after the Civil War. The best book of this stage was La puerta de paja, runner-up to the prestigious Premio Nadal in 1953. He also wrote La tiara de Saitaphernes, Gamalandafa and La verídica historia del niño de dos cabezas de Promonta, which were not published during his lifetime.