Vetispiradiene synthase

Vetispiradiene synthase

In enzymology, a vetispiradiene synthase is an enzyme of Egyptian henbane that catalyzes the following chemical reaction:

trans,trans-farnesyl diphosphate rightleftharpoons vetispiradiene + diphosphate

Hence, this enzyme has one substrate, trans,trans-farnesyl diphosphate, and two products, vetispiradiene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming). Other names in common use include vetispiradiene-forming farnesyl pyrophosphate cyclase, pemnaspirodiene synthase, HVS, and vetispiradiene cyclase. This enzyme participates in terpenoid biosynthesis.


  • Back K, Chappell J "Cloning and bacterial expression of a sesquiterpene cyclase from Hyoscyamus muticus and its molecular comparison to related terpene cyclases". J. Biol. Chem. 270 7375–81.
  • Chappell J, Ricci P and Marco Y "Sesquiterpene cyclase is not a determining factor for elicitor- and pathogen-induced capsidiol accumulation in tobacco". Planta 205 467–476.
  • Mathis JR, Back K, Starks C, Noel J, Poulter CD, Chappell J "Pre-steady-state study of recombinant sesquiterpene cyclases". Biochemistry. 36 8340–8.
  • Yoshioka H, Yamada N, Doke N "cDNA cloning of sesquiterpene cyclase and squalene synthase, and expression of the genes in potato tuber infected with Phytophthora infestans". Plant. Cell. Physiol. 40 993–8.
  • Martin VJ, Yoshikuni Y, Keasling JD "The in vivo synthesis of plant sesquiterpenes by Escherichia coli". Biotechnol. Bioeng. 75 497–503.

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