Mathematics

• Vertex (geometry), a corner point of a polygon, polyhedron, tesselation, etc.
• Vertex (graph theory), a node in a graph
• Vertex (curve), a local extreme point of curvature

Physics

• Vertex (physics), a point where particles collide and interact
• Vertex (optics), a point where the optical axis crosses a lens surface
• Vertex algebra in conformal field theory
• Vertex function describing the interaction between a photon and an electron
• Vertex model in statistical mechanics, a discrete model of a physical system in which weights are associated with vertices of a grid graph.

Companies

• Vertex - Business Process Outsourcing, a business services provider spun off from United Utilities
• Vertex Pharmaceuticals, a biotech company
• Vertex Standard, a radiocommunication products company.
• Vertex Software, a Web applications software developer.

Music

• A song in In The Groove (video game)
• Vertex (album), an album by Buck 65
• Vertex (band), a band formed in 1996

Other

• Vertex (anatomy), the uppermost surface of the head of an arthropod or vertebrate