Mesquite is an extremely hardy, drought-tolerant plant because it can draw water from the water table through its long taproot (recorded at up to 190 ft in depth). However, it can also use water in the upper part of the ground, depending upon availability. The tree can easily and rapidly switch from utilizing one water source to the other.
Many people, especially ranchers, consider the tree a nuisance because they believe it competes with rangeland grasses for moisture. In many parts of Texas, particularly West and Central Texas, the proliferation of mesquite is partly responsible for lowering of groundwater tables. However, salt cedar has had a greater effect on water consumption, in some cases even displacing existing mesquite.
Eradicating mesquite is difficult because the plant's bud regeneration zone can extend down to 6 inches (150 mm) below ground level. The tree can regenerate from a piece of root left in the soil. Some herbicides are not effective or only partially effective against mesquite. Grubbing techniques for removal, while effective against short-term regrowth, are expensive, costing upwards of $70/acre ($17,000/km²).
New growth of mesquite has needle-sharp thorns up to 75 mm (3 in) long. The spines are tough enough to penetrate the soft soles of sneakers or similar footwear and can easily puncture tires.
When used in baking, the mesquite flour is used in combination with other flours – substitute ¼ cup-to-½ cup mesquite flour for each cup grain flour. Mesquite is used in breads, pancakes, muffins, cakes and even cookies. Mesquite can also flavour steaks, chicken, pork & fish. It can be added to vegetable stir-fries, scrambled eggs, soups, even ice cream.
Wild animals also eat mesquite bean pods, and in Death Valley coyote feces consisting almost entirely of mesquite beans and pods can often be seen.
As firewood, mesquite burns slow and very hot. When used to barbecue, the smoke from the wood adds a distinct flavor to the food. This is common in Texas-style barbecue, while in the Southeast, hickory is usually used. Artisans and woodcrafters in Northern Mexico claim that mesquite should be cut under the light of a full moon to avoid splitting. While this has not been proven, mesquite does take longer to cure than most hardwoods.
Cowboys on the famed King Ranch of South Texas used mesquite fires to heat their branding irons and also to cook their lunches. A slab of fajita meat (skirt steak) was laid skin side down directly on the mesquite coals and cooked to well done. Flour tortillas (stored in their chaps or chinks) were also heated directly on coals and rounded out the meal along with strong coffee.
The species Prosopis pallida was introduced to Hawaii in 1828 and is now very common in the drier coastal parts of the islands, where it is called the Kiawe tree, which is a prime source of monofloral honey production.
Mesquite has also been introduced to parts of Africa, Asia and Australia and is considered by the World Conservation Union as one of the world's most problematic invasive species.