MRNA (2'-O-methyladenosine-N6-)-methyltransferase

S-adenosyl-L-methionine + m₇G(5')pppAm $rightleftharpoons$ S-adenosyl-L-homocysteine + m₇G(5')pppm₆Am (mRNA containing an N₆,2'-O-dimethyladenosine cap)

Thus, the two substrates of this enzyme are S-adenosyl methionine and m7G(5')pppAm, whereas its two products are S-adenosylhomocysteine and m7G(5')pppm6Am (mRNA containing an N6,2'-O-dimethyladenosine cap).

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase. Other names in common use include messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase, S-adenosyl-L-methionine:mRNA, and (2'-O-methyladenosine-6-N-)-methyltransferase.

References

• Keith JM, Ensinger MJ, Mose B "HeLa cell RNA (2'-O-methyladenosine-N6-)-methyltransferase specific for the capped 5'-end of messenger RNA". J. Biol. Chem. 253 5033–9.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes