Vector (biology)

In epidemiology, a vector is an organism that does not cause disease itself but which transmits infection by conveying pathogens from one host to another.

A classic example is the anopheles mosquito which acts as a vector for the disease malaria by transmitting the malarial parasite plasmodium to humans. In this case plasmodium is harmless to the mosquito (its intermediate host) but causes the disease malaria in humans (its definitive host).

In molecular biology and genetic engineering a vector is a vehicle for transferring genetic material into a cell.

A viral vector is a virus which has been modified to transduct specific genetic material into a cell, e.g. for gene therapy.

A plasmid vector is made by splicing a DNA construct into a plasmid. Various techniques are then used to transfect the plasmid into the cell.

Epidemiology

There are two types of vector that convey infectious organisms to a host: mechanical and biological. Microbes do not multiply within mechanical vectors - mechanical vectors only physically transport microbes from host to host. In contrast, microbes must propagate within a biological vector before the biological vector can transmit the microbes.

• mosquito (malaria, St. Louis encephalitis, dengue fever, yellow fever, West Nile virus)
• flea (bubonic plague)
• tick (Lyme disease, rocky mountain spotted fever, tick-borne encephalitis)
• deer mouse (hantavirus)
• kissing bug (Triatominae) (Chagas Disease)
• bat (Rabies)

Molecular biology

Cell transformation and gene therapy

• adenovirus
• adeno-associated virus
• tobacco mosaic virus (plants)
• cytomegalovirus
• bacteriophage (bacteria)
• viral vector

DNA

• SV40 (Simian virus 40)
• Plasmid
• Yeast artificial chromosome (Chromosome walking, Positional cloning)
• Bacterial artificial chromosome (Shotgun sequencing)

See also

• Vector DNA
• Vector (disease)
• Vector control

References

• "Vector Control". World Health Organization, Global Malaria Programme, Retrieved on 2007-05-30.
• "Malaria Glossary". Centers for Disease Control and Prevention, Retrieved on 2007-05-30.

External links

• Gene Therapy Net
• The Rutgers University Center for Vector Biology