Vasco may refer to:

People:

• Vasco da Gama, a Portuguese explorer
• Vasco Fernandes (1475-1540), known as Grão Vasco, a Portuguese painter
• Vasco Núñez de Balboa, a Spanish conquistador
• Vasco Gonçalves, Prime Minister of Portugal from 1974 to 1975
• Vasco Joaquim Rocha Vieira, last Portuguese Governor of Macau
• Vasco Rossi, a contemporary Italian singer

Geography:

• Vasco da Gama, Goa, a major city in the state of Goa, India

Engineering:

• Vasco da Gama Bridge, in Lisbon, the longest bridge in Europe
• Vasco da Gama Tower, in Lisbon
• Vasco da Gama Shopping Center, in the Nation's Park Quarter, Northeast Lisbon

In sports:

• Club de Regatas Vasco da Gama, a Brazilian football club named after the explorer
• Vasco Sports Club, an Indian football club named after both the explorer and the Brazilian club
• Vasco da Gama (South Africa), a South African football club named after both the explorer and the Brazilian club
• Associação Desportiva Vasco da Gama, a Brazilian football club named after both the explorer and the Brazilian club

In business:

• VASCO — VASCO Data Security International, Inc., a public company with NASDAQ symbol VDST founded in 1997
• Vietnam Air Service Company, a regional airline in southern Vietnam. A subsidiary of Vietnam Airlines In fiction
• Vasco, a Franco-Belgian comic by Gilles Chaillet
• Jane Vasco, the lead character in the Painkiller Jane TV series

In music:

• The Vasco Era, an Australian rock/blues band.
• Vasco EP part 1, the first part of a two-part EP by minimal techno producer Ricardo Villalobos.

Other:

• Spanish for Basque
• Vasco, the abbreviation for the orchid genus Vascostylis