Uridine monophosphate synthetase
(UMPS) (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) is the enzyme
that catalyses the formation of uridine monophosphate
(UMP), an energy carrying molecule in many important biosynthetic pathways.
In humans, the gene that codes for this enzyme is located on the long arm of chromosome 3 (3q13). A UMP synthetase deficiency can result in a metabolic disorder called orotic aciduria.
Deficiency of this enzyme is an inherited autosomal recessive trait in Holstein cattle, and it will cause death before birth.