Uracilylalanine synthase

Uracilylalanine synthase

In enzymology, an uracilylalanine synthase is an enzyme that catalyzes the chemical reaction

O3-acetyl-L-serine + uracil rightleftharpoons 3-(uracil-1-yl)-L-alanine + acetate

Thus, the two substrates of this enzyme are O3-acetyl-L-serine and uracil, whereas its two products are 3-(uracil-1-yl)-L-alanine and acetate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O3-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase. Other names in common use include O3-acetyl-L-serine acetate-lyase (adding uracil), isowillardiine synthase, willardiine synthase, and 3-O-acetyl-L-serine:uracil 1-(2-amino-2-carboxyethyl)transferase.


  • Ahmmad MAS, Maskall CS and Brown EG "Partial-purification and properties of willardiine and synthase activity from Pisum sativum". Phytochemistry 23 265–270.
  • Ikegami F, Kaneko M, Lambein F, Kuo, Y-H and Murakoshi I "Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum". Phytochemistry 26 2699–2704.
  • Kuo, Y-H and Lambein F "Biosynthesis of the uracilylalanines willardiine and isowillardiine in higher plants". Phytochemistry 17 1571–1576.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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