, an O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
is an enzyme
the chemical reaction
in which a beta-D-GlcNAc
residue is transferred from UDP-D-GlcNAc to the fucose
residue of a fucosylated protein
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase. This enzyme is also called O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase. This enzyme participates in notch signaling pathway.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .
- Stanley P, Irvine KD, Haltiwanger RS, Vogt TF "Fringe is a glycosyltransferase that modifies Notch". Nature. 406 369–75.
- The CAS registry number for this enzyme class is .