He married Harriet Canning (13 April 1804-8 January 1876), the daughter of George Canning, former Prime Minister and Foreign Secretary, on 4 April 1825 at Gloucester Lodge in Brompton. The couple had seven children;

• Lady Elizabeth Joanna de Burgh (22 February 1826-26 February 1854); married Henry Lascelles, 4th Earl of Harewood
• Ulick Canning de Burgh, Lord Dunkellin (12 July 1827-16 August 1867)
• Lady Emily Charlotte de Burgh (19 October 1828-10 October 1912); married Richard Boyle, 9th Earl of Cork
• Lady Catherine de Burgh (c. 1830 - 8 April 1895)
• Lady Margaret Anne de Burgh (c. 1831 - 31 March 1888); married Wentworth Beaumont, 1st Baron Allendale
• Hubert George de Burgh-Canning, 2nd Marquess of Clanricarde (30 November 1832-12 April 1916)
• Lady Harriet Augusta de Burgh (c. 1834 - 18 January 1901)

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