U.S. Route 421 is a spur of U.S. 21. It runs for 941 miles (1,514 km) from Michigan City, Indiana, at U.S. 20 to Fort Fisher. The highway goes through the cities of Indianapolis, Indiana; Frankfort, Kentucky; Lexington, Kentucky; Harlan, Kentucky; Bristol, Tennessee; Winston-Salem, North Carolina; Greensboro, North Carolina; and Wilmington, North Carolina.

Route description

Major cities
Wilmington, North Carolina Greensboro, North Carolina Winston-Salem, North Carolina Bristol, Tennessee Harlan, Kentucky Lexington, Kentucky Frankfort, Kentucky Indianapolis, Indiana Michigan City, Indiana

North Carolina

U.S. 421 begins at Fort Fisher and heads through North Carolina's southeastern beaches to Wilmington. It then heads in a northwest direction through Clinton, Dunn, Lillington, Sanford and Siler City to the Piedmont Triad region. In Greensboro, it follows the Greensboro Urban Loop to I-40. After Winston-Salem, it passes through Wilkesboro and Boone (where it intersects the Blue Ridge Parkway) on its way through the mountains towards Bristol, Tennessee.

Tennessee

Virginia

Kentucky

U.S. 421 comes from Virginia into Harlan County, Kentucky, and exits at Trimble County at Milton, Kentucky, crossing the Ohio River into Madison, Indiana.

CITY	Street name
Harlan	Eugene Goss Parkway
Hyden	U.S. 421
Manchester	White Street
McKee	Wall Street
Berea	Kingston Highway
Richmond	Main Street
Lexington	Main Street
Midway	421 Bypass
Frankfort	Wilkinson Boulevard
New Castle	Main Street
Campbellsburg	Main Street
Bedford	Main Street

Indiana

There is a major change to how U.S. 421 intersects with I-74 in Decatur County, Indiana. The Indiana Department of Transportation has conceptual images as well as construction information. http://www.in.gov/indot/div/projects/i74greensburg/

External links

• Indiana Highway Ends: US 421