"Those Damned Blue Collar Tweekers" is the third single off Primus's 1991 album Sailing the Seas of Cheese. Unlike its preceding singles "Jerry Was a Racecar Driver" and "Tommy the Cat," "Those...Tweekers" did not feature an accompanying video. The song opens with Larry LaLonde on guitar and a reserved bassline from Les Claypool, from there alternating between his trademark slap bass and a quiet section for the vocals.
The song's narrative describes several different trades that the town's blue collar tweekers engage in, but, like many of the other story-telling songs in Primus's catalogue, lacks any clear, single meaning and leaves plenty of ambiguity in its lyrics. However, many have speculated the song is about truck drivers and "blue-collar workers" using methamphetamines.
The band's Woodstock 1994 performance of the song was particularly notable, with Claypool beginning a bass rendition of the Star Spangled Banner in homage to Jimi Hendrix's guitar performance of the national anthem decades before, but eventually apologizing to the crowd by saying "Sorry, I had to do it" and returning to the song.