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Turcot_syndrome
Turcot syndrome
Turcot syndrome is the association between familial adenomatous polyposis or Hereditary nonpolyposis colorectal cancer and brain tumors like medulloblastoma, malignant glioma. It was first reported by Canadian surgeon Jacques Turcot (1914- ) et al in 1959 and hence carries the first author's name.
The genetic basis of Turcot syndrome is uncertain.The gene most likely to be involved is APC gene in chromosome 5q. However, the syndrome has been claimed to be linked to various mutations in a number of genes. For example, the mismatch repair genes MLH1 or PMS2 .
Synonyms
- Brain tumor-polyposis syndrome
- Glioma-polyposis syndrome
See also
- Gardner syndrome is an association of hereditary intestinal polyps and osteomas.
References
External links
Wikipedia, the free encyclopedia © 2001-2006 Wikipedia contributors (Disclaimer)
This article is licensed under the GNU Free Documentation License.
Last updated on Tuesday September 30, 2008 at 17:40:41 PDT (GMT -0700)
View this article at Wikipedia.org - Edit this article at Wikipedia.org - Donate to the Wikimedia Foundation
This article is licensed under the GNU Free Documentation License.
Last updated on Tuesday September 30, 2008 at 17:40:41 PDT (GMT -0700)
View this article at Wikipedia.org - Edit this article at Wikipedia.org - Donate to the Wikimedia Foundation
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