is the association between familial adenomatous polyposis
or Hereditary nonpolyposis colorectal cancer
and brain tumors
, malignant glioma
. It was first reported by Canadian surgeon Jacques Turcot
(1914- ) et al
and hence carries the first author's name.
The genetic basis of Turcot syndrome is uncertain.The gene most likely to be involved is APC gene in chromosome 5q.
However, the syndrome has been claimed to be linked to various mutations in a number of genes. For example, the mismatch repair genes MLH1 or PMS2 .
- Brain tumor-polyposis syndrome
- Glioma-polyposis syndrome
- Gardner syndrome is an association of hereditary intestinal polyps and osteomas.