The French established a mission among the Tunica around the year 1700, on the Yazoo River near the Mississippi River in the present-day state of Mississippi. Archaeological evidence suggests that they had recently migrated to the region from eastern Arkansas, in the late 17th century. Father Antoine Davion was assigned as the missionary for the Tunica as well as the smaller tribes of the Yazoo, Courouias, and Couspe (or Houspe) Indians. Unlike the northern Indians that the French were familiar with, the Tunica (and the nearby Taensa and Natchez) had complex religion, with temples, idols, and a priest class. The Tunica, Taensa, and Natchez retained chiefdom characteristics, such as a complex religion, after they had disappeared elsewhere.
During the Natchez War of 1729, the Tunica were forced to migrate south into present-day Louisiana. The Tunica, along with other tribes along the lower Mississippi River, were subjected to Chickasaw slave raids, for the South Carolina slave trade. An estimated 1,000 to 2,000 slaves were captured from the Tunica, Taensa, and Arkansas Indians by 1715 (Gallay, 2002).
The Tunica Biloxi were also hunters and gatherers, but most of all traders. They mostly traded salt from the many salt domes found in Louisiana.