, a tryptophan transaminase
is an enzyme
the chemical reaction
- L-tryptophan + 2-oxoglutarate (indol-3-yl)pyruvate + L-glutamate
Thus, the two substrates of this enzyme are L-tryptophan and 2-oxoglutarate, whereas its two products are (indol-3-yl)pyruvate and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-tryptophan:2-oxoglutarate aminotransferase. Other names in common use include L-phenylalanine-2-oxoglutarate aminotransferase, tryptophan aminotransferase, 5-hydroxytryptophan-ketoglutaric transaminase, hydroxytryptophan aminotransferase, L-tryptophan aminotransferase, and L-tryptophan transaminase. This enzyme participates in tryptophan metabolism. It employs one cofactor, pyridoxal phosphate.
- George H, Gabay S "Brain aromatic aminotransferase. I. Purification and some properties of pig brain L-phenylalanine-2-oxoglutarate aminotransferase". Biochim. Biophys. Acta. 167 555–66.
- O'Neil SR, DeMoss RD "Tryptophan transaminase from Clostridium sporogenes". Arch. Biochem. Biophys. 127 361–9.
- Tangen O, Fonnum F and Haavaldsen R "Separation and purification of aromatic amino acid transaminases from rat brain". Biochim. Biophys. Acta 96 82–90.
- The CAS registry number for this enzyme class is .
Gene Ontology (GO) codes