Tryptoline is a natural organic amine. It is an alkaloid chemically related to tryptamines. Derivatives of tryptoline have a variety of pharmacological properties and are known collectively as tryptolines.
Tryptolines are also potent reuptake inhibitors of 5-hydroxytryptamine and epinephrine; a significantly greater uptake inhibitory selectivity being shown for 5-hydroxytryptamine than epinephrine. The comparison of the inhibition kinetics of tetrahydro-β-carbolines for 5-hydroxytryptamine and epinephrine uptake (with that of the platelet aggregation response to these amines) have shown that 5-hydroxymethtryptoline, methtryptoline, and tryptoline are poor inhibitors of uptake. In all respects 5-hydroxytryptoline and 5-methoxytryptoline showed greater pharmacological activity than the tryptoline and methtryptoline.
Although the in vivo formation of tryptolines has been a matter of controversy, they have profound pharmacological activity.
Wipo Publishes Patent of X-Rx for "Tryptoline Derivatives Having Kinase Inhibitory Activity and Uses Thereof" (American Inventors)
Jul 19, 2013; GENEVA, July 19 -- Publication No. WO/2013/106414 was published on July 18.Title of the invention: "Tryptoline DERIVATIVES...