O'Higgins may refer to
to the following Irish politicians (all related):
or to:
- Bernardo O'Higgins (1778–1842), the Chilean revolutionary leader, or to places or ship named after him:
- Ambrosio O'Higgins, Marquis of Osorno (1720?-1801), colonial governor of Spanish America, his father
- O'Higgins Region, Chile
- O'Higgins Commune, Capitán Prat Province, Aysén Region, Chile
- Villa O'Higgins, the capital of the O'Higgins Commune
- Club Deportivo O'Higgins, a football club from Chile
- Bernardo O'Higgins Station, Antarctica
- O'Higgins Park, Santiago, Chile
- O'Higgins, a frigate commanded by Thomas Cochrane, 10th Earl of Dundonald
- O'Higgins Glacier, a glacier in the Southern Patagonian Ice Field