Trans-cinnamate 2-monooxygenase

Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

In enzymology, a trans-1,2-dihydrobenzene-1,2-diol dehydrogenase is an enzyme that catalyzes the chemical reaction

trans-1,2-dihydrobenzene-1,2-diol + NADP+ rightleftharpoons catechol + NADPH + H+

Thus, the two substrates of this enzyme are trans-1,2-dihydrobenzene-1,2-diol and NADP+, whereas its 3 products are catechol, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is trans-1,2-dihydrobenzene-1,2-diol:NADP+ oxidoreductase. This enzyme is also called dihydrodiol dehydrogenase. This enzyme participates in metabolism of xenobiotics by cytochrome p450.

Structural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , and .

References

  • AYENGAR PK, HAYAISHI O, NAKAJIMA M, TOMIDA I "Enzymic aromatization of 3,5-cyclohexadiene-1,2-diol". Biochim. Biophys. Acta. 33 111–9.

External links

The CAS registry number for this enzyme class is .

Gene Ontology (GO) codes

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