Topham Beauclerk entertained Dr. Johnson at his home in Old Windsor for a number of weeks. He appears several times in Boswell's Life of Johnson. As Bennet Langton records: 'His affection for Topham Beauclerk was so great, that when Beauclerk was labouring under that severe illness which at last occasioned his death, Johnson said, (with a voice faultering with emotion,) "Sir, I would walk to the extent of the diameter of the earth to save Beauclerk"' (Boswell 1072).
Beauclerk died at his house in Great Russell Street, Bloomsbury on 11 March 1780. Lady Diana later sold the house to retire in modesty to Richmond. The house at Great Russell Street, which was demolished in 1788, housed a library designed by renowned architect Robert Adam.